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Exosomes Derived from miR-129-5p Modified Bone Marrow Mesenchymal Stem Cells Represses Ventricular Remolding of Mice with Myocardial Infarction

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Researchers found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines.
[Journal of Tissue Engineering and Regenerative Medicine]
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Abstract
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