Altered H3 Histone Acetylation Impairs High-Fidelity DNA Repair to Promote Cerebellar Degeneration in Spinocerebellar Ataxia Type 7

Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.