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Targeting SYK of Monocyte-Derived Macrophages Regulates Liver Fibrosis via Crosstalking with Erk/Hif1α and Remodeling Liver Inflammatory Environment

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Scientists found that inhibition of monocyte-derived macrophages (MoMFs) SYK impaired the expression of CXCL1, reduced the recruitment of inflammatory cells, and promoted the phenotype cross-dress process of pro-resolution MoMFs, thereby remodeling the chronic inflammatory environment of the fibrotic liver.
[Cell Death & Disease]
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