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Congenital Deficiency Reveals Critical Role of ISG15 in Skin Homeostasis

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Investigators described two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment and characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.
[Journal of Clinical Investigation]

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