Novel Proteinase-Activated Receptor-2 (PAR2) Antagonist C391 Inhibits Alternaria-Induced Human Airway Epithelial Signaling In Vitro and Asthma Indicators in Acute Exposure Murine Models

Investigators developed C391, a potent proteinase-activated receptor-2 (PAR2) antagonist effective in blocking peptidomimetic- and trypsin-induced PAR2 signaling in vitro as well as reducing inflammatory PAR2-associated pain in vivo.