Transglutaminase 2 Mediates UVB-Induced Matrix Metalloproteinase-1 Expression by Inhibiting Nuclear p65 Degradation in Dermal Fibroblasts

In the skin, UV-irradiation increases expression of matrix metalloproteinases (MMPs) that causes dysregulation of extracellular matrix homeostasis in dermis, leading to acceleration of skin aging. Researchers reported the role of transglutaminase 2 in mediating the UVB-induced expression of MMP-1.