Intra-Islet Glucagon Confers β-Cell Glucose Competence for First-Phase Insulin Secretion and Favors GLP-1R Stimulation by Exogenous Glucagon

Researchers reported that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit first phase glucose-stimulated insulin secretion.