DOT1L Inhibition Enhances Pluripotency beyond Acquisition of Epithelial Identity and without Immediate Suppression of the Somatic Transcriptome

The authors found that, despite the enrichment of histone 3 lysine 79 methylation on thousands of actively transcribed genes in somatic cells, disruptor of telomeric silencing 1-like (DOT1L) inhibition did not immediately cause the shutdown of the somatic transcriptional profile to enable transition to pluripotency.