Immunomodulatory Matrix-Bound Nanovesicles Mitigate Acute and Chronic Pristane-Induced Rheumatoid Arthritis

Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.