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TP53 Promotes Lineage Commitment of Human Embryonic Stem Cells through Ciliogenesis and Sonic Hedgehog Signaling

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Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Researchers probed the potential links among these cancer traits by inactivating TP53 in hESCs.
[Cell Reports]
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