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A Combined Cell and Gene Therapy Approach for Homotopic Reconstruction of Midbrain Dopamine Pathways Using Human Pluripotent Stem Cells

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Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human PSC-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.
[Cell Stem Cell]
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AbstractGraphical Abstract
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