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PLP2-Derived Peptide Rb4 Triggers PARP-1-Mediated Necrotic Death in Murine Melanoma Cells

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Researchers studied the antitumor activity of peptide Rb4 derived from Proteolipid protein 2 (PLP2). In vitro, Rb4 induced F-actin polymerization, prevented F-actin depolymerization and increased the ER-derived cytosolic calcium.
[Scientific Reports]

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