The Interaction of CD4⁺ Helper T Cells with Dendritic Cells Shapes the Tumor Microenvironment and Immune Checkpoint Blockade Response

Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.