Loss of IRF7 Accelerates Acute Myeloid Leukemia Progression and Induces VCAM1-VLA-4 Mediated Intracerebral Invasion

The authors used MLL-AF9-induced AML mouse models with interferon regulatory factor 7 (IRF7) knockout or overexpression and xenograft mouse models to explore the intrinsic effects of IRF7 in AML.