TCRαβ-Depleted Haploidentical Grafts Are a Safe Alternative to HLA-Matched Unrelated Donor Stem Cell Transplants for Infants with Severe Combined Immunodeficiency

Researchers studied transplant outcomes in severe combined immunodeficiency (SCID) infants according to donor type, specifically TCRαβ/CD19-depleted haploidentical family donor transplant, and conditioning, through retrospective cohort analysis of 52 consecutive infants with SCID transplanted between 2013 and 2020.