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Pharmacodynamic Modeling and Exposure-Response Assessment of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders

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A hematopoietic transit model was developed to describe the joint effects of reducing influx from pro-B cells and accelerating CD20+ B cell depletion in the blood by inebilizumab.
[British Journal of Clinical Pharmacology]

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Abstract
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