Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Competitive Inhibition of Ephrin-A1 and EphA2 Binding by Perillaldehyde Leads to Decreased TRPM2 Expression and Reduced Mitochondrial Damage in Vascular Endothelial Cells
[International Immunopharmacology] Scientists elucidated the molecular mechanisms underlying perillaldehyde-mediated endothelial protection through the establishment of endothelium-specific TRPM2 transgenic and knockout murine models.
Endothelial Dysfunction in Cardiovascular Diseases: Mechanisms and In Vitro Models
[Molecular and Cellular Biochemistry] The authors synthesize currently available in vitro models regarding endothelial cell dysfunction, emphasizing cardiovascular diseases. They focused on 2D cell culture models, 3D cell culture systems, and models.
EYLEA HD® (Aflibercept) Injection 8 Mg sBLA Accepted for FDA Priority Review for Both the Treatment of Macular Edema following Retinal Vein Occlusion (RVO)...
[EYLEA HD® (aflibercept) Injection 8 mg sBLA Accepted for FDA Priority Review for Both the Treatment of Macular Edema Following Retinal Vein Occlusion (RVO) and for Monthly Dosing in Approved Indications] Regeneron Pharmaceuticals, Inc. announced that the US FDA accepted for Priority Review the supplemental Biologics License Application (sBLA) for EYLEA HD® Injection 8 mg. The sBLA seeks approval for EYLEA HD for both the treatment of macular edema following RVO, and for broadening the dosing schedule to include monthly dosing across approved indications.
Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis
[Lymphatic Research and Biology] Investigators characterized the transcriptional and translational responses of lymphatic endothelial cells during murine utaneous leishmaniasis using single-cell RNA sequencing data combined with flow cytometry and in vivo puromycin incorporation to assess translational activity.
Ant Colony-Inspired Adaptive Peptide Nanoregulators Remodeling the Endothelial Barrier to Alleviate Inflammatory Response
[ACS Nano ] A strategy was proposed inspired by the “ant colony collaboration”, developing an “all-in-one” conformationally adaptive peptide nanoregulator through the intelligent integration of three functional peptides.
Endothelial Piezo1 Stimulates Angiogenesis to Offer Protection against Intestinal Ischemia-Reperfusion Injury in Mice
[Molecular Medicine] Investigators explored the specific roles and underlying mechanisms by which endothelial Piezo1 was involved in intestinal ischemia–reperfusion injury.
Endothelial Dysfunction Drives Atherosclerotic Plaque Macrophage-Dependent Abdominal Aortic Aneurysm Formation
[Nature Immunology] Using a mouse model that combined cigarette smoke exposure and hypercholesterolemia, the authors demonstrated that cigarette smoke exacerbated atherosclerosis, leading to elastin fragmentation, aneurysm formation, rupture, and death.
CYR61 Delivery Promotes Angiogenesis during Bone Fracture Repair
[npj Regenerative Medicine] Researchers mapped the distribution of endogenous cysteine-rich angiogenic inducer 61 (CYR61) during bone repair and evaluate the effects of recombinant CYR61 delivery on vascularized bone regeneration.
Non-Enzymatic Modification of Aminophospholipids Induces Angiogenesis, Inflammation, and Insulin Signaling Dysregulation in Human Renal Glomerular Endothelial Cells In Vitro
[Free Radical Biology and Medicine] Human renal glomerular endothelial cells cells were exposed to non-enzymatically modified phosphatidylethanolamine by advanced glycation end-products, non-modified phosphatidylethanolamine, employed as a negative control, and lipopolysaccharides as a positive control.
Intussusceptive Angiogenesis-on-a-Chip: Evidence for Transluminal Vascular Bridging by Endothelial Delamination
[Proceedings of The National Academy of Sciences of The United States of America] Investigators used a microvessel-on-a-chip strategy, creating a microconduit coherently lined with flow-sensitive endothelial cells but in which transluminal bridges also formed.
Biocon Biologics Announces US FDA Approval for Jobevne™, Biosimilar Bevacizumab, Expanding Its Oncology Portfolio
[Biocon Biologics] Biocon Biologics announced that the US FDA has approved Jobevne™, a biosimilar Bevacizumab for intravenous use. JOBEVNE is a VEGF inhibitor that binds with VEGF and blocks the interaction with its receptors to prevent angiogenesis.
NexThera Completes First Patient Enrollment in US Clinical Trial for ‘NT-101,’ an Eye Drop Treatment for Wet AMD
[NexThera Co., Ltd. (BioSpace)] NexThera Co., Ltd. announced that it has completed the first patient enrollment for its Phase I/IIa clinical trial of NT-101, a novel eye drop treatment for wet AMD, at a clinical trial site in Pennsylvania.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
