NewslettersOrganoid News Methionine Oxidation Activates Pyruvate Kinase M2 to Promote Pancreatic Cancer Metastasis By lbeveridge - June 27, 2022 0 Chemoproteomic profiling of pancreatic organoids revealed that ethionine sulfoxide reductase A loss resulted in the selective oxidation of a methionine residue in pyruvate kinase M2. [Molecular Cell] Abstract