NewslettersESC & iPSC NewsNeural Cell NewsOrganoid News Type-I-Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease By lbeveridge - July 11, 2022 0 Knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescued the down syndrome microglial phenotypes both during brain development and in response to pathological tau. [Cell Stem Cell] AbstractGraphical Abstract