publication

Researchers developed a system to quantify Y chromosome gain or loss in patient-derived prostate cancer organoids. Using this system, they observed Y chromosome loss in 4 of the 13 patient-derived metastatic...

[Nature Communications] Researchers described a case of gene therapy-related T cell acute lymphoblastic leukemia that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission.

[Journal For Immunotherapy Of Cancer] Investigators highlighted the interaction between bipositive TAMs or cancer cells and T cells was predominantly focused on FXYD6+ T cells rather than regulatory T cells, whereas, FXYD6+ T cells were further identified as a group of novel immunosuppressive T cells.

[Blood] Scientists elucidated the molecular architecture and kinetics preceding AML relapse by utilizing error-corrected next-generation sequencing in 74 AML patients relapsing after alloHCT evaluating 140 samples from peripheral blood collected 0.6 to 14 months before relapse.

[Blood] Investigators performed a retrospective multicenter study via the EBMT registry on 306 children with IEI undergoing first transplant between 2010-2019 from an HLA-mismatched donor using TCRαβ or PTCY.

[Scientific Reports] Investigators reported that α-melanocyte-stimulating hormone, not ultraviolet (UV) UVA and UVB, acted as a major stimulus of melanogenesis in melanoma cells.