NewslettersMuscle Cell News Inactivation of Sirt6 Ameliorates Muscular Dystrophy in Mdx Mice by Releasing Suppression of Utrophin Expression By lbeveridge - July 25, 2022 0 Scientists demonstrated that SIRT6 deacetylated H3K56ac in myofibers to suppress expression of utrophin, a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin. [Nature Communications] Abstract