NewslettersNeural Cell News SPTLC1 Variants Associated with ALS Produce Distinct Sphingolipid Signatures through Impaired Interaction with ORMDL Proteins By lbeveridge - July 29, 2022 0 Scientists showed that ORMDL binding to the holoenzyme complex was impaired in cells expressing pathogenic SPTLC1-ALS alleles, resulting in increased sphingolipid synthesis and a distinct lipid signature. [Journal of Clinical Investigation] AbstractFull Article