SLIT2 Promoter Hypermethylation-Mediated SLIT2-IT1/miR-218 Repression Drives Leukemogenesis and Predicts Adverse Prognosis in Myelodysplastic Neoplasm

SLIT2 promoter methylation was markedly increased in myelodysplastic neoplasm/AML patients compared with controls and was correlated with poor clinical phenotype and outcome.