NewslettersCancer Stem Cell News Impaired Proteolysis of Non-Canonical RAS Proteins Drives Clonal Hematopoietic Transformation By lbeveridge - August 1, 2022 0 The authors identified that loss of LZTR1, or leukemia-associated mutants in the LZTR1 substrate and RAS GTPase RIT1 which escaped degradation, drove hematopoietic stem cell expansion and leukemia in vivo. [Cancer Discovery] Abstract