Loss of Function of OTUD7A in the Schizophrenia- Associated 15q13.3 Deletion Impairs Synapse Development and Function in Human Neurons

To tie OTU deubiquitinase 7A (OTUD7A) loss-of-function (LoF) with any schizophrenia-relevant cellular phenotypes, scientists modeled the OTUD7A LoF mutation, rs757148409, in human induced pluripotent stem cell (hiPSC)-derived induced excitatory neurons (iNs) by CRISPR-Cas9 engineering.