Context-Dependent Tumor-Suppressive BMP Signaling in Diffuse Intrinsic Pontine Glioma Regulates Stemness through Epigenetic Regulation of CXXC5

Scientists showed that bone morphogenetic protein ligands exerted potent tumor-suppressive effects against H3.3K27M and ACVR1 WT diffuse intrinsic pontine glioma in a SMAD-dependent manner.