NewslettersProstate Cell News A Genome-Wide CRISPR-Cas9 Knockout Screen Identifies Novel PARP Inhibitor Resistance Genes in Prostate Cancer By lbeveridge - August 12, 2022 0 The authors generated multiple knockout populations per gene in C4 and/or LNCaP CRPC cells, which confirmed that loss of PARP1, ARH3, YWHAE, or UBR5 caused olaparib resistance. [Oncogene] Full Article