New Diterpenes From the Marine Sponge Spongionella sp. Overcome Drug Resistance in Prostate Cancer by Inhibition of P-Glycoprotein

Researchers discovered that spongionellol A and 15,16-dideoxy-15α,17β-dihydroxy-15,17-oxidospongian-16-carboxylate-15,17-diacetate exhibited high activity and selectivity in human prostate cancer cells, including cells resistant to hormonal therapy and docetaxel.