NewslettersOrganoid News DNA Sensor Associated Type I Interferon Signaling Is Increased in Ulcerative Colitis and Induces JAK-Dependent Inflammatory Cell Death in Colonic Organoids By lbeveridge - September 29, 2022 0 The effects of type I IFN, IFN-γ, and TNF-α on gene expression, cytokine production and cell death were investigated in human colonic organoids. [American Journal of Physiology-Gastrointestinal and Liver Physiology] Abstract