NewslettersPulmonary Cell News Liposomal UHRF1 siRNA Shows Lung Fibrosis Treatment Potential by Regulating Fibroblast Activation By Bob - September 29, 2022 0 Investigators found that growth factor–β1-mediated upregulation of UHRF1 repressed Beclin1 via promoter methylation induction which resulted in fibroblast activation and lung fibrosis both in vitro and in vivo. [JCI Insight] AbstractGraphical Abstract