PDIA3 Activity Promotes Extracellular Accumulation of Proteins Relevant to Basal Breast Cancer Outcomes in Human MDA-MB-A231 Breast Cancer Cells

Scientists showed that either prior PDIA3-inhibition by the disulphide isomerase inhibitor 16F16 or depletion of heparin-binding proteins strongly reduced the activity of conditioned medium of MDA-MB-231 human breast cancer cells to support pro-migratory cell spreading and F-actin organisation by newly adherent MDA-MB-231 cells.