NewslettersPancreatic Cell News NF1 Loss of Function as an Alternative Initiating Event in Pancreatic Ductal Adenocarcinoma By Laurisa Dohm - November 22, 2022 0 Genetic experiments demonstrated that NF1 ablation culminated in acinar-to-ductal metaplasia, an early step in PDAC, and NF1 haploinsufficiency resulted in a dramatic acceleration of KrasG12D-driven PDAC. [Cell Reports] Full Article