NewslettersESC & iPSC News BNIP3-Dependent Mitophagy Safeguards ESC Genomic Integrity via Preventing Oxidative Stress-Induced DNA Damage and Protecting Homologous Recombination By Noshin Noorjahan - November 23, 2022 0 Researchers showed that BNIP3-dependent mitophagy protected genomic integrity in mESCs. Deletion of Bnip3 increased cellular reactive oxygen species and decreased ATP generation. [Cell Death & Disease] Full Article