Cancer Immunotherapies Transition Endothelial Cells into HEVs That Generate TCF1⁺ T Lymphocyte Niches through a Feed-Forward Loop

By employing single-cell transcriptomics, endothelial fate mapping, and functional multiplex immune profiling, researchers demonstrated that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs).