NewslettersCell Therapy News Overcoming On-Target, Off-Tumor Toxicity of CAR T Cell Therapy for Solid Tumors By Bob - December 5, 2022 0 Scientists summarize current clinical evidence of off-tumor toxicity (OTOT) with CAR T cells in the treatment of solid tumours and discuss the utility of preclinical mouse models in predicting clinical OTOT. [Nature Reviews Clinical Oncology] Abstract