NewslettersHematopoiesis News Mutant NPM1 Hijacks Transcriptional Hub to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia By Jamie Kang - December 6, 2022 0 For the first time, scientists comprehensively proved nucleophosmin (NPM1c) bonded to a subset of active gene promoters in NPM1c AMLs, including well-known leukemia-driving genes – HOXA/B cluster genes and MEIS1. [Cancer Discovery] Abstract