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Jamie Kang

Histological and Immunohistochemical Analyses of Articular Cartilage During Onset and Progression of Pre- and Early-Stage Osteoarthritis in a Rodent Model

[Scientific Reports] On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed.

Fibroblast Expression of Transmembrane Protein Smoothened Governs Microenvironment Characteristics After Acute Kidney Injury

[Journal Of Clinical Investigation] Researchers reported that Smo-specific ablation in fibroblasts reduced tubular cell apoptosis and inflammation, enhanced perivascular mesenchymal cells activities, and preserved kidney function after acute kidney injury.

Brain Delivery of Protein Therapeutics by Cell Matrix-inspired Biomimetic Nanocarrier

[Advanced Materials] Inspired by the natural environment of active proteins, scientists used the cell matrix components hyaluronic acid and protamine to self-assemble with proteins to form a protein-loaded biomimetic core and then incorporated it into ApoE3-reconstituted high-density lipoprotein to form a protein-loaded biomimetic nanocarrier.

In Vitro Development of a Muscle-Tendon Junction Construct Using Decellularised Extracellular Matrix: Effect of Cyclic Tensile Loading

[Biomaterials Advances] Decellularized extracellular matrix-derived from sheep muscle tendon junction (MTJ) was used to provide a scaffold for the MTJ with the relevant mechanical properties and differentiation cues such as the relase of growth factors.

NIH Awards Hesperos Research Grant to Develop Animal-Free Botox Testing Platform

[Hesperos, Inc.] Hesperos was awarded a $2 million research grant by the National Center for Advancing Translational Sciences in collaboration with the US FDA. The goal of the effort is to develop an advanced testing platform capable of assessing the potency of the Botulinum Toxin without the need for animal testing.

Establishment of Human Hematopoietic Organoids for Evaluation of Hematopoietic Injury and Regeneration Effect

[Stem Cell Research & Therapy] To manufacture hematopoietic organoids, researchers obtained CD34+ hematopoietic stem and progenitor cells from human embryonic stem cells using stepwise induction and immunomagnetic bead-sorting.

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Downregulation of Mirlet7 miRNA Family Promotes Tc17 Differentiation and Emphysema via De-repression of RORγt

[eLife] The authors demonstrated that loss of the Mirlet7b/Mirlet7c2 cluster in T cells predisposed mice to exaggerated cigarette smoke- or nanosized carbon black-elicited emphysema.

Iron Overload–Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function

[Inflammation] Investigators observed a significant increase in iron concentration during acute lung injury, accompanied by elevated levels of lipid peroxidation markers such as malonaldehyde and 4-hydroxynonenal.

Sfrp5 Overexpression Reverses oxLDL-Induced Lipid Accumulation in HVSMCs

[Bioscience, Biotechnology, and Biochemistry] Researchers found that Sfrp5 expression in oxLDL-treated human vascular smooth muscle cells (HVSMCs) was downregulated. Sfrp5 overexpression inhibited the viability of HVSMCs induced by oxLDL.