NewslettersHepatic Cell News Increased CHCHD2 Expression Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis via Notch/Osteopontin Signaling By lbeveridge - December 9, 2022 0 Coiled-coil-helix-coiled-coil-helix domain-containing (CHCHD2)-overexpressing hepatocytes activated hepatic stellate cells by upregulating osteopontin levels, a downstream mediator of Notch signals. [JCI Insight] Full ArticleGraphical Abstract