NewslettersProstate Cell News SETDB1 Modulates Degradation of Phosphorylated RB and Anti-Cancer Efficacy of CDK4/6 Inhibitors By Noshin Noorjahan - January 13, 2023 0 Investigators demonstrated that RING finger domain protein TRIM28 bound and promoted ubiquitination and degradation of CDK4/6-phosphorylated retinoblastoma protein. [Cancer Research] Abstract