NewslettersHuman Immunology News CD28-CAR-T Cell Activation through FYN Kinase Signaling Rather Than LCK Enhances Therapeutic Performance By Laurisa Dohm - January 24, 2023 0 Scientists found that LCK-deficient CAR-T cells were strongly signaled through CAR and had better in vivo efficacy with reduced exhaustion phenotype, as well as enhanced induction of memory and proliferation. [Cell Reports Medicine] Full ArticleGraphical Abstract