Catechol-O-Methyl Transferase Suppresses Cell Invasion and Interplays with MET Signaling in Estrogen Dependent Breast Cancer

To delineate catechol-O-methyl transferase (COMT) role in metastasis of estrogen receptor dependent breast cancer, scientists investigated the effect of COMT overexpression on invasion, transcriptome, proteome and interactome of MCF7 cells stably transduced with lentiviral vector carrying COMT gene.