Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.
[Cellular Signalling]
EGFR and Lyn Inhibition Augments Regorafenib Induced Cell Death in Sorafenib Resistant 3D Tumor Spheroid Model
