Lnc956-TRIM28-HSP90B1 Complex on Replication Forks Promotes CMG Helicase Retention to Ensure Stem Cell Genomic Stability and Embryogenesis

Investigators identified an uncharacterized long noncoding RNA NONMMUT028956 (Lnc956) predominantly expressed in mESCs. Lnc956 was accumulated on replication forks to prevent fork collapse and preserve genomic stability and was essential for mouse embryogenesis.