Igf1 Regulates Fibrocartilage Stem Cells, Cartilage Growth, and Homeostasis in the Temporomandibular Joint of Mice

The authors investigated the functional role of Igf1 in fibrocartilage stem cells for temporomandibular jointcartilage growth and homeostasis by lineage tracing using Gli1-CreER+; Tmflfl mice and conditional Igf1 deletion using Gli1-/Col2-CreER+; Igf1fl/fl mice.