Therapeutic Activation of Endothelial Sphingosine-1-Phosphate Receptor 1 by Chaperone-Bound S1P Suppresses Proliferative Retinal Neovascularization

Researchers showed in a mouse model of oxygen-induced retinopathy that endothelial overexpression of S1pr1 suppressed while endothelial knockout of S1pr1 worsened neovascular tuft formation.