NewslettersMesenchymal Cell News Higenamine Promotes Osteogenesis via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice By Jamie Kang - March 14, 2023 0 Higenamine treatment resulted in an enhanced bone formation and prevented accelerated bone loss on two animal models that mimic spontaneous senile osteoporosis and postmenopausal osteoporosis. [Journal Of Bone And Mineral Research] Abstract