NewslettersCell Therapy News Tumor-Intrinsic Sensitivity to the Pro-Apoptotic Effects of IFN-γ Is a Major Determinant of CD4+ CAR T-Cell Antitumor Activity By Jamie Kang - May 29, 2023 0 With the help of functional intravital imaging, scientists reported that interferon (IFN)-γ production but not perforin-mediated cytotoxicity was the dominant mechanism for tumor elimination by anti-CD19 CD4+ CAR T cells. [Nature Cancer] Full Article