Phosphorylation of IWS1 by AKT Maintains Liposarcoma Tumor Heterogeneity Through Preservation of Cancer Stem Cell Phenotypes and Mesenchymal-Epithelial Plasticity

Researchers showed that the AKT-mediated phosphorylation of the transcription elongation factor IWS1, promoted the maintenance of CSCs in both cell and xenograft models of liposarcoma.