NewslettersESC & iPSC News The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis By lbeveridge - May 31, 2023 0 Scientists identified a function of cyclin F to regulate substrate solubility and showed how cyclin F mechanistically underlay amyotrophic lateral sclerosis and frontotemporal dementia disease pathogenesis. [Molecular Neurobiology] Full Article