An Increased Demand of FAD Synthesis in Differentiated and Stem Pancreatic Cancer Cells Is Accomplished by Modulating FLAD1 Gene Expression

The FAD synthesis process was evaluated in two PDAC cell lines: PANC-1 and PANC-1 derived cancer stem cells (CSCs), presenting the R273H mutation in the oncosuppressor p53, as well as MiaPaca2 and MiaPaca2 derived CSCs, presenting the R248W mutation in p53.